Medical device systems for use in renal denervation and other forms of neuromodulation of the autonomic nervous system, consisting of guiding catheters, medical guidewires, medical introducers; Medical devices, medical device systems consisting of medical devices, medical apparatus, and medical instruments, all for treating heart failure, chronic kidney disease, end stage renal disease, myocardial infarction, anxiety, contrast nephropathy, diabetes, metabolic disorder and insulin resistance; energy emitting catheter-based systems consisting of medical devices and devices for medical procedures in the nature of neuromodulation and denervation of the autonomic nervous system for use in treating a variety of medical conditions, also consisting of guiding catheters, medical guidewires, medical introducers