Medical devices for minimally invasive surgery; medical devices for surgical suturing; medical devices for use in the approximation of soft tissues, including medical devices for repair of tissues and for tissue ligation and fixation and for the fixation of meshes and other implants or devices; endoscopic medical devices, namely, medical devices for suturing through flexible endoscope; endoscopic medical devices for plication or fixation or closure of holes or perforations; hernia repair device; medical devices that enable distribution of tension, applied to tissue while suturing, over a larger surface area of a tissue anchor instead of over a smaller surface area of the suture itself; medical devices that reduce entrapment of blood vessels and nerves; medical devices using anchors or implants, namely, medical devices for surgically deploying anchors or implants in tissue; medical devices for automatic or semi-automatic of suturing or placement of stitches in medical procedures; threading medical device, namely, for use in surgical threading; medical instrument for repairing of tissue defects, anastomosis of vessels or organs, anchoring or fixating soft or hard tissue or prosthesis material or implant, closing natural or artificial tissue openings, modifying anatomical spaces, lifting, stretching, pulling or retracting tissues or organs or implants or prosthetic material using open or minimally invasive approaches