Pharmaceutical research services, namely, the design and usage of enabling software tools for protein structure determination and derivation, candidate binding site determination on macrobiomolecule structures and rapid examination and ranking of ligand binding in silico; the design and usage of enabling hardware and software tools for the generation and handling of data from biological assays and for the graphing and visualization of that data by the end user; the design, synthesis, and utilization in research of small, nested and familied molecules, as well as services encompassing the design, synthesis and utilization in research of chemical compounds elaborated from the foregoing small molecules; all for use in the search for ligands effective in modulation of the action of therapeutically relevant macrobiomolecules, particularly proteins; and consultation services related thereto