medical diagnostic and therapeutic preparations and devices for administering same, sold filled with diagnostic and therapeutic preparations or separately as a kit, all for administration via diverse routes of administration, including through the respiratory airways, and medical devices for administering the pharmaceuticals, sold filled or separately as a kit, the preparations including polynucleotides, proteins and/or organic molecules for medical use, including macromolecules such as anti-sense oligonucleotides and enzymes and small organic and inorganic molecules for treatment of human and non-human animal respiratory, central nervous system, neoplastic, endocrine, immune and cardiovascular ailments, including bronchoconstriction, difficult breathing, impeded and obstructed lung airways, allergy(ies) and/or inflammation, which in some cases are adenosine receptor associated symptoms,; pharmaceutical preparations for testing, and preventing and therapeutically treating respiratory, airway and pulmonary diseases and conditions, such as asthma, pulmonary vasoconstriction, inflammation, allergies, impeded respiration, Acute Respiratory Distress Syndrome (ARDS), renal damage and failure, ischemia, resulting from the administration of certain drugs, including adenosine stress tests, infantile Respiratory Distress Syndrome (infantile RDS), pain, cystic fibrosis, allergic rhinitis, allergic bronchitis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), as well as cancers including leukemias, lymphomas, carcinomas, and the like, e.g., colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, etc., as well as all metastatic cancers, e.g.; cancers which metastasized to the lung(s), breast, liver and prostate included