Describing and providing services for scientific and medical research services, namely, screening of oligonucleotide libraries to identify active anti-sense oligonucleotides for use in pharmaceutical preparations for administration via various routes, including respiratory airways, for testing and prophylaxis and therapeutic treatment of human and non-human animal ailments that may be associated with hyper-sensitivity or hyper-responsiveness to adenosine, including bronchoconstriction, difficult breathing, impeded and obstructed lung airways, allergy(ies) and/or inflammation, which in many cases are adenosine receptor associated symptoms, particularly testing, preventing and therapeutically treating respiratory, airway, pulmonary and other diseases and conditions, such as asthma, pulmonary vasoconstriction, inflammation, allergies, asthma; impeded respiration, Acute Respiratory Distress Syndrome (ARDS), renal damage and failure, ischemia, administration of certain drugs, including adenosine and other drugs for, for example, treating SupraVentricular Tachycardia (SVT), adenosine stress tests, infantile Respiratory Distress Syndrome (infantile RDS), pain, cystic fibrosis, allergic rhinitis, ___ bronchitis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), as well as cancers including leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc., as well as all other metastatic cancers, e.g. cancers which metastasized to the lung(s), breast and prostate