Downloadable computer software, software development kits, software libraries, downloadable software platforms, downloadable software in the form of container images and virtual machine appliances, pre-trained downloadable machine learning models, and executable software tools, all featuring artificial intelligence and machine learning for use in enterprise scientific research, industrial research and development, and technical optimization, namely hypothesis generation, iterative experimental design, and test-time learning during inference, autonomous problem-solving on open scientific, engineering, and mathematical problems, computational discovery and optimization of biological compounds, chemical compounds, therapeutic interventions, and engineered materials, computational optimization of industrial and biological processes, computational optimization of software systems and computational performance, for use by software engineers and engineering teams, mathematical and operations-research optimization of complex scientific, engineering, and industrial systems and multi-agent reasoning systems for scientific research and engineering teams